Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (29): 5379-5383.doi: 10.3969/j.issn. 2095-4344.2012.29. 013

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Xenogeneic cancellous bone for repairing segmental bone defects in rabbit radius

Wei Ji-rong1, Zhang Ying2, Lin Yong-liang3   

  1. 1School of Graduated Student, Southern Medical University, Guangzhou 510515, Guangdong Province, China;
    2Department of Traumatic Orthopedics, General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou 510510, Guangdong Province, China;
    3Department of Research and Development, Guangdong Guanhao Biological Technology Company, Guangzhou 510663, Guangdong Province, China
  • Received:2012-03-22 Revised:2012-03-22 Online:2012-07-15 Published:2012-07-15
  • Contact: Zhang Ying, Doctor, Master’s supervisor, Chief physician, Department of Traumatic Orthopedics General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou 510510, Guangdong Province, China
  • About author:Wei Ji-rong★, Master, Physician, School of Graduated Student, Southern Medical University, Guangzhou 510515, Guangdong Province, China fimmutrumpet@ qq.com

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Abstract:

BACKGROUND: Xenogeneic cancellous bone has a natural porous structure that facilitates the ingrowth of new bone. Besides, its antigenicity can be eliminated completely after treatment and cannot induce immune rejection. Moreover, it has good bone conduction.
OBJECTIVE: To evaluate the effect of xenogeneic bone on the repair of segmental bone defects in rabbit radius.
METHODS: Totally 36 rabbits (4-6 months old, 2.5-3.5 kg, no gender limitations) were randomly divided into three groups: experimental group, control group and blank group. A rabbit model of 15 mm-long segmental bone defects in the radius was established. Rabbits in the experimental group were implanted with biological xenogeneic bone, and those in the control group were implanted with deep frozen allogenic bone, while the blank group had no treatment. At weeks 4, 8 and 12 after operation, rabbits in the three groups were observed by general observation, anatomy observation, X-ray examination and histological examination.
RESULTS AND CONCLUSION: At weeks 4, 8 and 12 after operation, bone defects in the experimental and control groups were repaired gradually, but no repair was found in the blank group. The radiographic and histological scores were both higher in the experimental and control groups than the blank group (P < 0.05). The radiographic and histological scores between the experimental and control groups had no significant difference. These results suggest that biological xenogeneic bone is good to repair bone defects; in addition, the repair effect of biological xenogeneic bone is the same as that of xenogeneic bone.

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